Smokers at risk from their own 'second-hand' smoke

It is well known that smokers damage their health by directly inhaling cigarette smoke. Now, research published in BioMed Central's open access journal Environmental Health has shown that they are at additional risk from breathing environmental tobacco smoke, contrary to the prevailing assumption that such risks would be negligible in comparison to those incurred by actually smoking. Maria Teresa Piccardo worked with a team of researchers from the National cancer Research Institute, Genoa, Italy, to study the exposure of newsagents in the city to harmful cigarette smoke. She said, "Newsagents were chosen because they work alone in small newsstands, meaning that any tobacco smoke in the air they breathe is strictly correlated to the number of cigarettes smoked by that newsagent. We studied the contribution environmental tobacco smoke made to carcinogen exposure in 15 active smokers."

The researchers found that environmental tobacco smoke may have a significant impact on smokers' health. For someone who smokes 14 cigarettes a day, their own second hand smoke resulted in exposure the equivalent of smoking an extra 2.6 cigarettes. According to Piccardo, "Both active and passive smoking contributions should always be considered in studies about health of active smokers."
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Slightly bizarre piece of research. In Italy, newsstands are large cubicles with the vendor hiding inside, hence the idea that they would be breathing in their own second-hand smoke. It doesn't take a genius to figure that if second-hand smoke has a measurable effect then it would also have one on the first-hand smoker. I guess it never occurred to the researchers that these people were also inhaling second-hand exhaust fumes.

If your first cigarette gave you a buzz and you now smoke, blame a gene

Anyone who has ever tried smoking probably remembers that first cigarette vividly. For some, it brought a wave of nausea or a nasty coughing fit. For others, those first puffs also came with a rush of pleasure or "buzz." Now, a new study links those first experiences with smoking, and the likelihood that a person is currently a smoker, to a particular genetic variation. The finding may help explain the path that leads from that first cigarette to lifelong smoking.

The new finding also adds to growing suspicion surrounding the role of a particular nicotine-receptor gene in smoking-related behaviors and in lung cancer. The regular smokers in the study were far more likely than the never-smokers to have the less common rs16969968 form of the CHRNA5 gene, in which just one base-pair in the gene sequence was different from the more common form. This kind of genetic variation is called a single nucleotide polymorphism or SNP.

Smokers were also eight times as likely to report that their first cigarettes gave them a pleasurable buzz.

"It appears that for people who have a certain genetic makeup, the initial physical reaction to smoking can play a significant role in determining what happens next," says senior author and project leader, Ovide Pomerleau, a professor of psychiatry at the University of Michigan Medical School and founder of the U-M Nicotine Research Laboratory.

"If cigarette smoking is sustained, nicotine addiction can occur in a few days to a few months," he adds. "The finding of a genetic association with pleasurable early smoking experiences may help explain how people get addicted — and, of course, once addicted, many will keep smoking for the rest of their lives."